Frontal Alpha Asymmetry during Sleep in Depression
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2018-09-01
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en
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Abstract
This study was conducted to examine the presence of frontal alpha asymmetry
during sleep among major depression patients and healthy controls, which is
related to the di erence in lateralization of alpha power. The objective was to
relate frontal alpha asymmetry during sleep to resting state encephalogram
studies, where the asymmetry has been suggested to be a biomarker for
depression. It was hypothesized that the patient group will show altered sleep
patterns in comparison to healthy controls. Furthermore, the alpha power was
expected to be increased in the left hemisphere in MDD patients. Moreover, it
was expected that female responders to anti-depressants would show increased
right-sided alpha power. The hypotheses were partially supported. There was no
major di erence in asymmetry among MDD patients and control group. As
expected, female responders did show increased right-sided alpha power, but only
in sleep stage 1. Furthermore, male responders showed the same pattern but for
sleep stage 2 and sleep stage 3. This study was one of the few studies relating the
asymmetry to sleep. The results found here contribute to the understanding of
the asymmetry during sleep and showed possible connections to resting state
asymmetry research. Further investigation is needed to conclude whether the
found di erences between female and male responders and non-responders across
the sleep stages are meaningful and may re
ect sleep- and MDD-related processes,
such as emotional processing or executive control.
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Faculteit der Sociale Wetenschappen