IMPAIRED mPFC-DEPENDENT SPATIAL WORKING MEMORY IN THE APO-SUS RAT MODEL FOR SCHIZOPHRENIA
| dc.contributor.advisor | Martens, Gerard | |
| dc.contributor.advisor | Maas, Dorien | |
| dc.contributor.author | Pavlidi, Lydia | |
| dc.date.issued | 2018-01-30 | |
| dc.description.abstract | The neurobiology underlying cognitive symptomatology in schizophrenia (SZ) remains poorly understood and untreated. Prefrontal (PFC) dysconnectivity and both a redox imbalance and oligodendrocyte (OL) dysfunction are thought to be involved in SZ. To study the cognitive symptoms, we used the APO-SUS rat model for SZ. At the behavioral level of the symptoms we focused on the medial PFC (mPFC) and working memory (WM). We report a dysfunctional/immature mPFC in the APO-SUS rats as was evident from the deficits observed in the social interaction test and spatial working memory deficits that were repeatedly shown in three different mPFC-dependent tasks: the continuous delayed alternation, repeated reversal learning and spatial win-shifting. At the molecular level and various ages (PND21, PND90, PND365) APO-SUS rats had altered mRNA expression levels of redox-related genes in the cingulate cortex (Cg), the hippocampus (HPC) and barrel cortex (BC), indicating a general redox impairment. Finally, we report that APO-SUS rats do not differ from APO-UNSUS rats in the mRNA expression levels of myelin- or OL-related genes in Cg, HPC and BC, which together with previous studies from our group indicates an mPFC-specific myelin and OL deficit. We conclude that APO-SUS rats have a redox imbalance that is not mPFC specific but rather spread throughout the brain and a spatial working memory deficit that is mPFC dependent. | en_US |
| dc.embargo.lift | 2044-01-30 | |
| dc.embargo.type | Tijdelijk embargo | en_US |
| dc.identifier.uri | https://theses.ubn.ru.nl/handle/123456789/7688 | |
| dc.language.iso | en | en_US |
| dc.thesis.faculty | Faculteit der Sociale Wetenschappen | en_US |
| dc.thesis.specialisation | Researchmaster Cognitive Neuroscience | en_US |
| dc.thesis.studyprogramme | Researchmaster Cognitive Neuroscience | en_US |
| dc.thesis.type | Researchmaster | en_US |
| dc.title | IMPAIRED mPFC-DEPENDENT SPATIAL WORKING MEMORY IN THE APO-SUS RAT MODEL FOR SCHIZOPHRENIA | en_US |