Replicability and Uniqueness of Tremor Characteristics in Parkinson’s Disease
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2019-07-01
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en
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Abstract
Parkinson’s disease (PD) is a heterogeneous disease characterized by bradykinesia,
rigidity, and resting tremor. While bradykinesia and rigidity have a consistent response to
mediation, resting tremor has not. Research into the causes of heterogeneous responses of
tremor to medication is necessary, as patients describe tremor as their second most
bothersome symptoms, and clinicians are currently forced to follow a trial-and-error approach
when treating this symptom. Therefore, this study aims at identifying replicable and unique
tremor-characteristics that might be used to identify subpopulations of PD to predict the most
suitable treatment. We measured patients with PD on two occasions. We assessed replicability
of the clinical severity of the tremor, frequency and amplitude in rest and during cognitivecoactivation,
the spatial correlation within the tremor-amplitude related network, and the
stability of the peak activation location within this network. We observed high replicability of
clinical- and accelerometry characteristics. Spatial correlations and Euclidean distances were
not replicable between days. We conclude that clinical- and accelerometry parameters might
be suitable for identification of subgroups of patients, but our fMRI-derived parameters seem
uninformative for clinical practice.
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Faculteit der Sociale Wetenschappen