Outcome Predictors in ERP-treatment of Patients with Obsessive Compulsive Disorder
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2020-07-06
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en
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Introduction: Concentrated Exposure Treatment (cET) encompasses intensive forms of Exposure and Response Prevention (ERP) treatment for patients with an obsessive-compulsive disorder (OCD). Although predictor studies are available for less-intensive forms of OCD-treatment, such studies are not available for cET. This is the first study to assess predictors for cET-effectiveness. Method: The effect of cET on OCD-scores was measured at post-treatment, 3-month, and 6-month follow-up using a repeated measures ANOVA. Pre-treatment OCD severity, depressive symptomatology, and age of onset were used as predictors of remission and treatment response in multiple binary logistic regression analyses, with treatment programme (4-day/8-day) as covariate. Results: cET is associated with reducing OCD-severity post-treatment at all follow-up measurements (p < .0001 for all measurements). For the predictors, pre-treatment OCD severity is not predictive of remission or treatment response. Higher depressive symptomatology is predictive of lower remission rates at post-treatment (p = .036) and at 3-month follow-up (p = .036). Early OCD-onset is predictive of higher treatment response at post-treatment (p = .012). Predictors are not significant at other follow-up measurements. Discussion: cET is an effective form of treatment for OCD, for which predictors appear to exist to a limited extend. Limitations exist on randomisation, available follow-up data, and recall bias on symptomatologic onset. Strict re-coding in accordance with consensus remission- and treatment response criteria results in data-loss. Replication studies are needed.
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Faculteit der Sociale Wetenschappen