Investigating fronto-striatal connectivity and the influence of genetic variation in DRD2 and PER2 in adult ADHD patients and healthy subjects
Keywords
No Thumbnail Available
Authors
Issue Date
2014-08-01
Language
en
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Adult Attention-Deficit/Hyperactivity Disorder (ADHD) is a psychiatric disorder characterized by inattentiveness and/or hyperactive and impulsive symptoms. Previous studies have reported alterations in fronto-striatal functioning in children and adults with ADHD and suggested disturbances in the dopamine system as well as disturbances in circadian rhythm. The present study took a seed-to-seed approach, and a seed-to-whole-brain approach to compare fronto-striatal connectivity at rest between adult ADHD patients and healthy people. There was no significant connectivity between the right nucleus accumbens and the right IFG, but a more medial resting-state network involving right and left basal ganglia and the orbitofrontal cortex was found. However, no significant differences in this network between adult ADHD patients and healthy people emerged.
Description
Citation
Supervisor
Faculty
Faculteit der Sociale Wetenschappen